The Rural Municipality of Macdonald is located in south central Manitoba, and is situated adjacent to the southwestern boundary of Winnipeg, Manitoba's capital city.
The municipality is accessible by Winnipeg's Perimeter Highway 101, Provincial Trunk Highway 3 and Provincial Trunk Highway 2. Macdonald is also located along Provincial Road 330. Macdonald is well located along a major rail line, which provides quick and easy rail transfer access to Canadian and U.S.A. markets.
The La Salle River, a tributary of the Red River, winds through the municipality. The La Salle River provides many picturesque river front properties and recreation opportunities throughout the municipality. Major communities in Macdonald include Oak Bluff, La Salle, Domain, Brunkild, Sanford, Starbuck and Osborne.